solimena group


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Anastasiou V, Ninou E, Alexopoulou D, Stertmann J, Müller A, Dahl A, Solimena M, Speier S, Serafimidis I, Gavalas A.
Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice.
Diabetologia. 2015 Oct 31 (Pubmed)

Petzold A, Solimena M, Knoch KP
Mechanisms of Beta Cell Dysfunction Associated With Viral Infection.
Curr Diab Rep. 2015 Oct;15 (Pubmed)

Ehehalt F, Sturm D, Rösler M, Distler M, Weitz J, Kersting S, Ludwig B, Schwanebeck U, Saeger HD, Solimena M, Grützmann R.
Blood Glucose Homeostasis in the Course of Partial Pancreatectomy--Evidence for Surgically Reversible Diabetes Induced by Cholestasis.
PLoS One. 2015 Aug 6 (Pubmed)

Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun Ü, Solimena M, Simons K, Levental I, Schwille P.
Adaptive lipid packing and bioactivity in membrane domains.
PLoS One. 2015 Apr 23 (Pubmed)

Dehghany J, Hoboth P, Ivanova A, Mziaut H, Müller A, Kalaidzidis Y, Solimena M, Meyer-Hermann M.
A Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells.
Traffic. 2015 Aug  (Pubmed)

Hoboth P, Müller A, Ivanova A, Mziaut H, Dehghany J, Sönmez A, Lachnit M, Meyer-Hermann M, Kalaidzidis Y, Solimena M.
Aged insulin granules display reduced microtubule-dependent mobility and are disposed within actin-positive multigranular bodies.
Proc Natl Acad Sci U S A. 2015 Feb 17  (Pubmed)

Torkko JM, Primo ME, Dirkx R, Friedrich A, Viehrig A, Vergari E, Borgonovo B, Sönmez A, Wegbrod C, Lachnit M, Münster C, Sica MP, Ermácora MR, Solimena M.
Stability and targeting of proICA512/IA-2 to insulin secretory granules requires β4-sheet mediated dimerization of its ectodomain in the endoplasmic reticulum.
Mol Cell Biol. 2015. [Epub ahead of print] (PubMed)


Bornstein SR, Amiel SA, Rubino F, Mingrone G, Kamvissi V, Solimena M, Bonifacio E, Jones P, Schwarz P, Birkenfeld AL, Behrens A, Barthel A, Lechler R, Peakman M.
Creating a "Transcampus" in Diabetes Research Between King's College London and the Technische Universität Dresden: Update on Islet Biology and Transplantation.
Horm Metab Res. 2014. [Epub ahead of print]. (PubMed)

Noguera ME, Primo ME, Jakoncic J, Poskus E, Solimena M, Ermácora MR.
X-ray structure of the mature ectodomain of phogrin.
J Struct Funct Genomics. 2014. [Epub ahead of print]. (PubMed)

Marciniak A, Cohrs CM, Tsata V, Chouinard JA, Selck C, Stertmann J, Reichelt S, Rose T, Ehehalt F, Weitz J, Solimena M, Slak Rupnik M, Speier S.
Using pancreas tissue slices for in situ studies of islet of Langerhans and acinar cell biology.
Nat Protoc. 2014; 9(12):2809-22. (PubMed)

Knoch KP, Nath-Sain S, Petzold A, Schneider H, Beck M, Wegbrod C, Sönmez A, Münster C, Friedrich A, Roivainen M, Solimena M.
PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells.
Mol Metab. 2014; 14;3(5):518-30. (PubMed)


Magro MG, Solimena M.
Regulation of beta cell function by RNA-binding proteins.
Mol Met. 2013; 2(4):348-55. (PubMed)

Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, Bornstein SR.
Transplantation of human islets without immunosuppression.
Proc Natl Acad Sci U S A. 2013; 110(47):19054-8. (PubMed)

Phieler J, Chung KJ, Chatzigeorgiou A, Klotzsche-von Ameln A, Garcia-Martin R, Sprott D, Moisidou M, Tzanavari T, Ludwig B, Baraban E, Ehrhart-Bornstein M, Bornstein SR, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T.
The Complement Anaphylatoxin C5a Receptor Contributes to Obese Adipose Tissue Inflammation and Insulin Resistance.
J Immunol. 2013; 191(8):4367-74. (PubMed)

Ivanova A, Kalaidzidis Y, Dirkx R, Sarov M, Gerlach M, Schroth-Diez B, Müller A, Liu Y, Andree C, Mulligan B, Münster C, Kurth T, Bickle M, Speier S, Anastassiadis K, Solimena M.
Age-dependent labeling and imaging of insulin secretory granules.
Diabetes. 2013; 62(11):3687-96. (PubMed)

Krautz C, Wolk S, Steffen A, Knoch KP, Ceglarek U, Thiery J, Bornstein S, Saeger HD, Solimena M, Kersting S.
Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets.
Diabetologia. 2013; 56(7):1596-604.

Sturm D, Marselli L, Ehehalt F, Richter D, Distler M, Kersting S, Grützmann R, Bokvist K, Froguel P, Liechti R, Jörns A, Meda P, Baretton GB, Saeger HD, Schulte AM, Marchetti P, Solimena M.
Improved protocol for laser microdissection of human pancreatic islets from surgical specimens.
J Vis Exp. 2013; (71). doi:pii: 50231. 10.3791/50231.


Heni M, Ketterer C, Wagner R, Linder K, Böhm A, Herzberg-Schäfer SA, Machicao F, Knoch KP, Fritsche A, Staiger H, Häring HU, Solimena M.
Polymorphism rs11085226 in the gene encoding Polypyrimidine-tract binding protein 1 negatively affects glucose-stimulated insulin secretion.
PLoS One. 2012; 7(10):e46154. (PubMed)

Dirkx R Jr, Solimena M.
Cholesterol-enriched membrane rafts and insulin secretion.
J Diabet Invest. 2012; 3(4):339-346.

Bonner SM, Pietropaolo SL, Fan Y, Chang Y, Sethupathy P, Morran MP, Beems M, Giannoukakis N, Trucco G, Palumbo MO, Solimena M, Pugliese A, Polychronakos C, Trucco M, Pietropaolo M.
Sequence variation in the promoter of the Ica1 gene, which encodes a protein implicated in type 1 diabetes, causes the transcription factor AIRE to increase its binding and downregulate expression.
J Biol Chem. 2012; 287(21):17882-93. (PubMed)

Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M.
Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.
Diabetologia. 2012; 55(4):1013-23. Epub 2012 Jan 18. (PubMed)


Primo ME, Jakoncic J, Noguera ME, Risso VA, Sosa L, Sica MP, Solimena M, Poskus E, Ermácora MR.
Protein-protein interactions in crystals of  the human receptor-type protein tyrosine phosphatase ICA512 ectodomain.
PLoS One. 2011; 6(9):e24191. (PubMed)

Bötticher G, Sturm D, Ehehalt F, Knoch KP,  Kersting S, Grützmann R, Baretton GB, Solimena M, Saeger HD.
Isolation of Human Islets from Partially Pancreatectomized Patients.
J Vis Exp. 2011; (53). pii: 2962. doi: 10.3791/2962. (PubMed)

Steffen A, Ludwig B, Krautz C, Bornstein S, Solimena M.
Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry.
Islets. 2011; 3(5). (PubMed)

Suckale J, Wendling O, Masjkur J, Jäger M, Münster C, Anastassiadis K, Stewart AF, Solimena M.
PTBP1 is required for embryonic development before gastrulation.
PLoS One. 2011; 6(2):e16992 (PubMed)


Geis C, Weishaupt A, Grünewald B, Wultsch T, Reif A, Gerlach M, Dirkx R, Solimena M, Perani D, Heckmann M, Toyka KV, Folli F, Sommer C.
Human stiff-person syndrome IgG induces anxious behavior in rats.
PLoS One. 2011; 6(2):e16775. (PubMed)

Ehehalt F, Knoch K, Erdmann K, Krautz C, Jäger M, Steffen A, Wegbrod C, Meisterfeld R, Kersting S, Bergert H, Kuhlisch E, Bornstein S, Bonifacio E, Saeger HD, Solimena M.
Impaired insulin turnover in islets from type 2 diabetic patients.
Islets. 2010; 2(1):30-6. (PubMed)

Liu Y, Suckale J, Masjkur J, Magro MG, Steffen A, Anastassiadis K, Solimena M.
Tamoxifen-independent recombination in the RIP-CreER mouse.
PLoS One. 2010; 5(10):e13533. (PubMed)

Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M.
β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules.
PLoS One. 2010; 5(9):e12929. (PubMed)

Solimena M, Speier S.
Insulin release: shedding light on a complex matter.
Cell Metab. 2010; 12(1):5-6.(PubMed)

Suckale J, Solimena M.
The insulin secretory granule as a signaling hub.
Trends Endocrinol Metab. 2010; 21(10):599-609. (PubMed)

Ries J, Bayer M, Csúcs G, Dirkx R, Solimena M, Ewers H, Schwille P.
Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy.
Opt Express. 2010; 18(11):11073-82. (PubMed)


Liu Y, Mziaut H, Ivanova A, Solimena M.
beta-Cells at the crossroads: choosing between insulin granule production and proliferation.
Diabetes Obes Metab. 2009; 11 Suppl 4: 54-64. (PubMed)

Reimann M, Bonifacio E, Solimena M, Schwarz PE, Ludwig B, Hanefeld M, Bornstein SR.
An update on preventive and regenerative therapies in diabetes mellitus.
Pharmacol Ther. 2009; 121: 317-31. (PubMed)


Suess C, Czupalla C, Winter C, Pursche T, Knoch KP, Schroeder M, Hoflack B, Solimena M.
Rapid changes of mRNA binding protein levels following glucose and IBMX stimulation of insulinoma INS-1 cells.
Mol Cell Proteomics. 2008; 8: 393-408. (PubMed)

Suess C, Solimena M.
Proteomic profiling of b-cells using a classical approach two-dimensional gel electrophoresis.
Exp Clin Endocrinol Diabetes. 2008; 116 Suppl 1: S13-20. (PubMed)

Trajkovski M, Mziaut H, Schubert S, Kalaidzidis Y, Altkrüger A, Solimena M.
Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512.
J Biol Chem. 2008; 283: 33719-29. (PubMed)

Suckale J, Solimena M.
Pancreas islets in metabolic signaling
Front Biosci. 2008; 13: 7156-71. (PubMed)

Meisterfeld R, Ehehalt F, Saeger HD, Solimena M.
Pancreatic disorders and diabetes mellitus.
Exp Clin Endocrinol Diabetes. 2008; 116 Suppl 1: S7-S12. (PubMed)

Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M.
ICA512 signaling enhances panreatic β-cell proliferation by regulating cyclins D through STATs.
Proc Natl Acad Sci USA. 2008; 105: 674-9. (PubMed)

Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M.
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Eur J Cell Biol. 2008; 87: 197-209. (PubMed)


Ehninger A, Mziaut H, Solimena M.
Emerging role of SUMO in pancreatic β-cells.
Horm Metab Res. 2007; 39: 658-64. (PubMed)


Borgonovo B, Ouwendijk J, Solimena M.
Biogenesis of secretory granules.
Curr Opin Cell Biol 2006; 18: 365-370 (PubMed)

Trajkovski M, Mziaut H, Schwarz PE, Solimena M.
Genes of type 2 diabetes in Beta cells.
Endocrinol Metab Clin North Am. 2006; 35: 357-369 (PubMed)

Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkruger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Muller S, Solimena M.
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5.
Nat Cell Biol. 2006; 8: 435-445 (PubMed)

Knoch KP, Meisterfeld R, Kersting S, Bergert H, Altkruger A, Wegbrod C, Jager M, Saeger HD, Solimena M.
cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells.
Cell Metabol. 2006; 3: 123-134 (PubMed)


Bergert H, Knoch KP, Meisterfeld R, Jager M, Ouwendijk J, Kersting S, Saeger HD, Solimena M.
Effect of oxygenated perfluorocarbons on isolated rat pancreatic islets in culture.
Cell Transplant. 2005; 14: 441-448 (PubMed)

Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M.
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.
J Cell Biol. 2005; 170: 607-618 (PubMed)


Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch KP, Müller S, Solimena M.
Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in β-cells.
J Cell Biol. 2004; 167: 1063-1074 (PubMed)

Yang Y, Lacas-Gervais S, Morest DK, Solimena M, Rasband M.
βIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier.
J Neurosci. 2004; 24(33): 7230-7240. (PubMed)

Murinson BB, Butler M, Marfurt K, Gleason S, De Camilli P, Solimena M.
Markedly elevated GAD antibodies in SPS: effects of age and illness duration.
Neurology Neurology. 2004; 63(11): 2146-2148. (PubMed) 

Lacas-Gervais S, Guo J, Strenzke N, Scarfone E, Kolpe M, De Camilli P, Moser T, Rasband M, Solimena M.
βIVΣ1 spectrin stabilizes nodes of Ranvier and axon initial segments.
J Cell Biol 2004; 166(7): 983-990. (PubMed)

Knoch KP, Bergert H, Borgonovo B, Saeger H.-D., Altkrüger A, Verkade P, Solimena M.
Polypyrimidine tract binding protein promotes insulin secretory granule biogenesis.
Nat Cell Biol. 2004; 6(3): 207-214. (PubMed)

Petzold GC, Marcucci M, Butler MH, van Landeghem FKH, Scholz P, Einhäupl KM, Solimena M, Valdueza JM, De Camilli P.
Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity.
Ann. Neurol. 2004; 55: 286-290. (PubMed)


Solimena M and Gerdes H-H.
Secretory granules: and the last shall be first....
Trends Cell Biol. 2003: 399-402. (PubMed)

Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, Solimena M.
Islet Cell Autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.
J. Biol. Chem. 2003; 278: 26166-26173. (PubMed)


Schmierer K, Grosse P, De Camilli P, Solimena M, Floyd S, Zschenderlein R.
Paraneoplastic stiff-person syndrome- no tumor progression over five years.
Neurology. 2002; 58: 148. (PubMed)


Ort T, Voronov S, Guo J, Zawalich K, Froehner S, Zawalich W, Solimena M.
Dephosphorylation of β-2 syntrophin and Ca2+/calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion.
EMBO J. 2001; 20:4013-4023. (PubMed)

Meinck H-M, Maile S, Faber L, Morgenthaler N, Seissler J, Butler M, Solimena M, DeCamilli P, Scherbaum WA. 2001.
Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases.
J. Neurol. Neurosurg. Psych. 2001; 71:100-103. (PubMed)

Berghs S, Ferracci F, Maksimova E, Gleason S, Leszczynski N, Butler M, De Camilli P, Solimena M.
Autoimmunity against β-IV-spectrin in paraneoplastic motor neuron syndrome. Proc Natl Acad Sci USA. 2001; 98: 6945-6950. (PubMed)


Solimena M and De Camilli, P.
Synaptic autoimmunity and the Salk factor.
Neuron. 2000; 28: 309-310. (PubMed)

Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel J-H, Zhang J-P, W. Philbrick W., Slepnev V, Ort T, Solimena M.
βIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system.
J. Cell Biol. 2000; 151: 985-1002. (PubMed)

Ort T, Maksimova E, Dirkx R, Kachinsky A, Berghs S, Froehner S, Solimena M.
The receptor tyrosine phosphatase like-protein ICA512 binds the PDZ domains of β2-syntrophin and nNOS in pancreatic β-cells.
Eur. J. Cell Biol. 2000; 79: 621-630. (PubMed)

Butler MH, Hayashi A, Ohkoshi N, Villman C, Beckerle C-M, Feng G, De Camilli P, Solimena M.
Autoimmunity to gephyrin in stiff-man syndrome.
Neuron. 2000; 26: 307-312. (PubMed)